Exosomes are a promising avenue for Longevity research, and some studies suggest they can delay the aging process. Exosomes are very small signaling proteins that are released by stem cells and contain proteins, lipids, and nucleic acids that can affect other cells.
At RegeneZone and The Hormone Zone, our physician experts use cutting-edge therapies to help with your Longevity Goals. Be sure to enquire with the office about the specifics.
Anti-inflammatory effects
Exosomes can suppress the activation and function of various inflammatory causing immune cells that may help with age-related inflammation call “inflammaging”.
Regulation of Cellular Senescence
Cellular senescence occurs when cells stop functioning, but do not die. These zombie cells secrete inflammatory proteins that negatively affect surrounding cells, leading to aging. Exosomes can modulate the genes that make cells become senescent and zombie-like thereby reducing the detrimental effects on tissue function.
Antioxidant Effects
Aging is associated with increased oxidative stress and cell death. Exosomes can enhance cellular antioxidant defenses, scavenge reactive oxygen species (ROS), and modulate programmed cell death and age related damage.
Promotes Blood Vessel Growth
As the body ages, blood vessel formation declines, which can impair tissue repair and contribute to age-related diseases. Exosomes can promote angiogenesis by stimulating endothelial cells to help new blood vessels grow.
Tissue repair and regeneration
Exosomes carry and secrete growth factors and other bioactive molecules that stimulate tissue repair and regeneration. This can help counteract age-related degeneration.
Epigenetic changes
Exosomes may help reverse age-related changes in DNA and help reverse age-related changes and promoting a youthful cellular state.
Waste removal
Exosomes may help remove damaged DNA fragments, oxidized and misfolded proteins
Cell to Cell Communication
One of the most important clinical aspects of Exosomes is their ability to send optimal signals to all tissues in order to improve their function.
The clinical uses of Exosomes for body aging treatments include:
Exosomes can promote collagen and fibrin synthesis, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Exosomes may also help with age-related inflammation and oxidative stress, the foundation for improved skin health.
Skincare: Exosomes can be applied topically to the skin in serums, creams, and masks.
Microneedling: Exosomes can be combined with microneedling to help them penetrate the skin more deeply.
Dermal Fillers: Exosomes can be mixed with dermal fillers to improve their performance and longevity.
Laser Treatments: Exosomes can be used to promote tissue repair and reduce inflammation after laser treatments.
Osteoarthritis and joint health: Exosomes have shown potential in treating age-related joint degeneration by promoting tendon, ligament, and cartilage repair, lowering inflammation, and improving the immune response.
Muscle regeneration: Age-related muscle loss, known as sarcopenia, can lead to reduced strength and mobility. Exosomes can promote muscle regeneration by stimulating satellite cells. When muscle tissue is damaged, satellite cells are activated and begin to proliferate, fusing with damaged muscle fibers to form new muscle tissue. Exosomes can help trigger this activation process.
Neurodegenerative diseases: Exosomes may help with age-related neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, by lowering inflammation in the brain called neuroinflammation. Exosomes can also promote brain cell survival and facilitate brain cell repair and regeneration.
Cardiovascular health: Exosomes can improve blood vessel function and promote new vessel growth (angiogenesis), which may help address age-related cardiovascular issues, such as atherosclerosis and ischemic diseases that lead to lowered blood flow that is related to poor exercise recovery and sexual dysfunction.
Metabolic health: Exosomes may help regulate blood sugar (glucose) and cholesterol (lipid) metabolism, improving insulin sensitivity and helping with metabolic disorders, such as Insulin Resistance and Type 2 Diabetes.
Anyone experiencing changes in skin appearance, joint function, muscle strength, and brain function, may benefit from Exosome therapy. If you are suffering from age-related conditions, such as osteoarthritis, neurodegenerative diseases such as Alzehimer’s or Parkinson’s Disease, or cardiovascular disease, OR you have joint pain, muscle spasms, water retention, fatigue, headaches, hair loss, sinus issues, excessive sweating, digestive issues, poor skin health, overweight, and memory problems, you may benefit from Exosome therapy as a part of a comprehensive treatment plan.
People are understanding more than ever that prevention and a proactive approach to health is the key to an optimal life. Many patients are also dealing with the problems of a poor diet with high sugar and processed foods, smoking and excessive alcohol, stress, digestive issues and leaky gut, and insomnia. Anyone who is proactive about maintaining their health as they age and are interested in cutting-edge therapies to promote overall well-being and counteract the problems of poor lifestyle habit, then Exosome therapy may be beneficial.
People seeking to improve the appearance of their skin by reducing fine lines and wrinkles, promoting new collagen growth, and improving skin elasticity may be interested in Exosome therapy as a part of their skincare program.
People who engage in regular physical activity and want to counteract age-related declines in muscle mass, strength, endurance, and joint health may find Exosome therapy helpful.
Exosomes are extracellular vesicles with a diameter of 30–200 nm and their activity can be maintained by storage at − 80 °C. Exosomes can transport fats, proteins, enzymes, polynucleotides, and other forms of RNA, including microRNA, messenger RNA, and non-coding RNA. Exosomes have a better safety profile than the MSCs that secrete them, are easier to preserve, and do not lose their function. Therefore, exosomes have emerged as a promising cell-free treatment for treating human sickness, and their properties have attracted the attention of researchers.
It has been demonstrated that neurons in the hippocampus, a crucial component for memories and learning, produce something called SIRT1. SIRT1 is the most evolutionarily conserved sirtuin in mammals. It is essential to a variety of biological functions, including the regulation of metabolism, stress response, genomic stability, and ultimately in aging. It has also been suggested that SIRT1, which regulates cellular energy and redox state and possesses NAD + -dependent protein acetylation activity, plays a factor in longevity because it fends off oxidative stress as we age and lengthens life. Therefore, we suggest that reducing oxidative stress and apoptosis via the SIRT1 signaling pathway could be a promising strategy for the prevention and treatment of age-related illnesses. Mesenchymal stem cell-derived exosomes (MSC-Exos) can reduce oxidative stress and apoptosis in neural tissue, thereby slowing brain aging.
Exosomes have therapeutic properties and applications in the regeneration and repair of skin tissue; they contribute to the regulation and promotion of the healing process by activating different pathways that can modulate the state of inflammation, promoting angiogenesis, proliferation, differentiation, cell migration, and apoptosis, and ensuring that the regular healing process takes place in situations it normally would not, such as diabetes, which affects the body’s natural healing and scarring processes, inhibiting its ability to recover the shape and function of the affected tissue. The pathways involved in exosome-mediated skin regeneration include MAPK, NRF2-KEAP1, AKT/mTOR, PI3k/AKT, ERK 1/2, and Wnt/β-catenin, among others. The use of stem cell-derived exosomes represents a promising strategy for the repair, regeneration, and treatment of malignant and non-malignant skin disorders.
Absolutely! Here a few references:
https://pubmed.ncbi.nlm.nih.
https://pmc.ncbi.nlm.nih.gov/
